MNSTC-I was commanded by US Army Lieutenant General Martin E. Dempsey (September 2005 — June 2007) and Lieutenant General David H. Petraeus (June 2004 — September 2005).

Multi-National Security Transition Command – Iraq (MNSTC-I) was the branch of the Multi-National Force - Iraq that is responsible for developing, organizing, training, equipping, and sustaining the Iraqi Security Ministries (Ministry of Defense (MoD) and Ministry of Interior (MoI)) and their associated Iraqi Security Forces (ISF), i.e. the military of Iraq and the Iraqi Police.